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This cation-starvation is detected by P. aeruginosa, leading to the induction of LPS modification genes and resistance to antimicrobial drugs, such as cationic antimicrobial peptides and aminoglycosides [32].
More specifically, the corresponding genes were found in a cluster involved in salivaricin biosynthesis which, in addition to salX and salY, contained the salA salivaricin structural gene, the salB and salT enzyme modification genes, and salR and salK, encoding a signal transduction system which is not homologous to BceRS.
The roles of these chromatin modification genes and their proteins products are not fully understood yet, but various studies have shown that the mutational status of these genes may possess prognostic influence on ccRCC.
15 Tiberius-only genes had predicted products that may modify the Bdellovibrio cell surface including putative adhesions, LPS modification or pilus fibre modification genes and secreted and membrane proteins, including a single PAS domain putative sensory protein.
Several subsets of genes were identified, including protein kinases, Ca2+-binding sensor proteins (CaM), genes responsive to oxidative stress, transcription factors, cell-wall modification genes and phytohormone-responsive genes.
This cation-starvation is detected by P. aeruginosa, leading to the induction of LPS modification genes and resistance to antimicrobial drugs, such as cationic antimicrobial peptides and aminoglycosides [ 32].
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Another region of interest, from 1,455 kb to 1,465 kb, encodes two Type I restriction modification genes hsdR and hsdS (CJM1_1490 and CJM1_1493) and the associated DNA methylase, hsdM, (CJM1_1494).
An RMS was identified as present when both the restriction and modification genes were present and adjacent on the chromosome.
According to Zhao et al. [ 26], filamentous cyanobacteria (Anabaena, Spirulina and Nostoc strains) contain more restriction and modification genes than unicellular cyanobacteria (Synechocystis, Synechococcus and Prochlorococcus strains).
Based on the proposed approach, hundreds of new type IIC enzymes can be generated using head-to-tail oriented type I, II, and III restriction and modification genes.
Based on the proposed approach, hundreds of novel type IIC enzymes could be generated from head-to-tail oriented type I, II and III restriction and modification genes.
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