This modification generates a new compound, which is a substrate for metabolizing enzymes, leading to a metabolite that is the expected active principle.
Previous reports have demonstrated that ECM modification generates a panoply of signalling pathways implicated in various physiological and pathophysiological events [ 29].
These structural modifications generate a NRVS spectrum of M13V/K22M that is noticeably different from that of wt as shown in Figure 2. In the 275 325 cm–1 spectral region, five distinct bands are resolved: the three-peak feature appearing at 290, 301, and 311 cm–1 now displays comparable NRVS intensities for all three bands, which is unlike that observed in wt and its M13V counterpart.
Glycosylation, the attachment of glycans (oligosaccharides) to proteins or lipids, is a ubiquitous post-translational modification that generates an extensive functional capability from a limited set of genes [8] [10].
The integration of molecular design with diamine modification generates synergistic effects for enhancing and fine tuning the molecular sieving potential of polyimide membranes.
Applying matching Phase II transformations to the hydroxyl group reaction center resulting from the Phase I modification generates two additional derivatives (Fig. 4, BPAII3 and BPAII4).
It has been reported that MG-induced albumin modification generates the cross-linked methylglyoxal dialkylimine radical cation and the enediol radical anion of methylglyoxal during the glycation process [ 24, 25].
Further modification generating the cyclic hemiacetal 4 containing a thiourea linker between the P3 and P2 sites exhibited potent inhibitory activities, high cornea permeability and excellent efficacy in the rat lens culture cataract model.
LodA is encoded in an operon that contains a second gene coding for LodB, a protein required for the post-translational modification generating the cofactor.
I don't even rule out the possibility of genetic modification generating some benign ideas, as long as we can keep them away from monopolists such as Monsanto.
