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investigate histone modification dynamics during the cold-induced epigenetic switching that occurs at the FLC locus during vernalization.
Our method enabled a systematic assessment of histone modification dynamics of all TFs during blood cell differentiation.
It would be highly desirable to investigate whether these dramatic histone modification dynamics of HPTFs have functional implications.
On short time scales the stochastic histone (de-) modification dynamics drives the system toward a quasi steady state.
These observations point to the possibility of predicting TFs with lineage-specific functions by assessing histone modification dynamics (hereafter refered to as the epigenetical approach).
By systematic assessment of histone modification dynamics of TFs during blood cell differentiation, we have shown that, HPTFs tend to have higher histone modification variations.
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Prompted by our analysis of genetic sequences, as a step in this direction we work with an expansion-modification dynamics introduced by Li [25], [26], where two processes converge, one related to permanence the other to change.
The influence of post-transcriptional modifications on dynamics was investigated for the related bmt tRNALeu.
To a lesser extent, genes encoding proteins playing roles in histone modifications, cytoskeleton dynamics, Golgi organization and biogenesis, proteasome, and cell cycle regulation (see Discussion below) are also discovered.
A time-varying asymmetric mesh stiffness model was built and employed in two typical gear dynamic models to simulate the effect of the addendum modification on gear dynamics.
Structural dynamics modification (SDM) has been widely used for improvements of built-in structures.
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