Exact(4)
Using protein occupancy and chromatin modification data from the ENCODE project, 1,394 of the most likely transcriptional regulatory elements were identified and termed putative transcriptional regulatory regions (pTRRs) [ 26].
To determine whether H1 and HMGD1 are associated with specific core histone PTMs, we downloaded a large set of S2 cell line histone modification data from the modENCODE project (Kharchenko et al., [ 34]).
When published histone modification data from the adult testis [ 50] were analyzed, the DMRs of clusters 1 and 2 showed enrichment in enhancer marks such as histone H3 lysine-4 monomethylation (H3K4me1) and histone H3 lysine-27 acetylation (H3K27ac) [ 51, 52] (Fig. 4c), suggesting that they are distal or intronic regulatory regions.
To investigate the association between gene expression activity and the occupancy of CTCF binding sites, we used a set of histone modification data from the Broad Institute [ 22] available from the ENCODE project (Additional file 6: Table S2), in combination with counts of histone marks in the flanking regions of each CTCF binding site (Fig. 2, Fig. 3a).
Similar(56)
We compared the chimpanzee data to histone modification data from three human iPSC lines from the Roadmap Epigenomics project.
The ChIP-seq of histone modification data from Mikkelsen et al [ 18] (the raw data can be downloaded at ftp://ftp.broad.mit.edu/pub/papers/chipseq/Mikkelsen2007/alignments/) including H3K27me3 (K27), H3K4me3 (K4) and H3K36me3 (K36) were used for the benchmarking test to evaluate the performance of our program QChIPat.
We added the histone modification data from Pokholok et al. [ 12], resulting in a total of 25 histone modifications.
To address this issue, we compare DNA methylation data from the fire ant Solenopsis invicta and the honey bee Apis mellifera to extensive histone modification data from D. melanogaster.
A benchmark testing data, the ChIP-seq of histone modification data from Mikkelsen et al [ 18], including H3K27me3 (K27), H3K4me3 (K4) and H3K36me3 (K36), was used for evaluating our program.
H3K4me3 modification data from one adult human PFC was downloaded from [ 39].
H3K4me3 modification data from neurons and non-neuronal cells of human PFC was downloaded from [ 33].
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