Sentence examples similar to modification damage from inspiring English sources

As carrier of genetic information, DNA is one of the most important intracellular targets that undergo modification and damage upon interaction with endogenous and exogenous factors.

Interestingly, chromatin modification, DNA damage response and DNA repair genes were also upregulated following exposure to either compound.

Parameters that allow the surface modification without damaging the "macro" structure of scaffolds were determined.

Their involvement in striated muscle regeneration or remodelling relies on the oxidative or proteolytic modification of damaged tissue, to allow phagocytosis of debris [ 97].

It is thus tempting to speculate that the initially reversible thiol modifications that we observe in chronologically aging yeast cells might in fact represent a 'pro-active' response of yeast cells to protect their proteins against irreversible protein modifications and damage, and thereby extend lifespan.

Indeed, OIS in culture has been a very useful system for the identification and characterization of senescence effector mechanisms, such as epigenetic gene regulation and chromatin modifications, DNA damage response, negative feedback in the PI3K pathway, and senescence-associated secretory phenotype (SASP /senescence-mess SASP /senescence-mess 14].

However, in contrast to p53, whose upregulation occurs mainly through post-translational modifications, DNA damage-induced upregulation of p73 occurs mainly by transcriptional induction.

Obviously, this is a unique advantage over rather simple macroscopic methods like microabrasive wear testing of UHMWPE [ 23] in cases when induced modifications and damages, respectively, just sporadically occur in micro-regions of a surface.

Each unwise modification created equipment damage.

Induction of sigmaE-dependent, sodium dodecyl sulfate-regulated genes and genes involved in mycolic acid modification pointed to damage and repair of the cell envelope.

Engineering tests were conducted to assess coating removal rate, physical substrate damage, modification of substrate properties, and impact on subsequent paint adhesion.