Exact(1)
Given the current limited knowledge of the energetics of RNA loops and tertiary interactions, however, microarray binding data do not provide a reliable check on secondary structures deduced from free energy minimization coupled with chemical modification constraints when the RNA has short helices and large loops.
Similar(59)
The evolutionary transitions between different types of chewing modes should be explained by moderate morpho-functional modifications constraint by the necessity of preservation of efficient occlusion [33], [35].
Comments like partial and complete disassembly, disassembly cost, optimum level of disassembly and finally, the modification of constraints are suggested in this work.
However, providing the designers with the ability to perform real-time geometric modification, assembly constraints specification and concurrent design of different components/sub-assemblies will enable designers to collaborate effectively during design.
From [8], linear programming-based approach to rout and rate maximization are adopted with modifications to constraints and routing path selection.
These interactions point out parts of the design that need to be improved, driving structural modifications or constraints specifications, to reduce the final testing effort.
It leads to the conclusion that the EMSINRC algorithm is in fact equivalent to a constraint modification leading to a new constraint given by Equation 79.
Finally, we explore objective function modifications and constraint addition as methods to improve performance.
Today, this duality can be accounted for by the countervailing influences of adaptive modification and the constraints of genetics, anatomy, and history, but for Paley, the intent of a designer provided the only conceivable answer.
Our linkage component is closely related to the time dependence of a particle filter model, and is merely a modification with additional constraints.
Although our results suggested that coevolution has maintained the interaction between ECR and USP, we could not detect any significant modification of evolutionary constraints in the dimerisation surface of ECR [ 8].
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