For example, the 9 proteins of cluster 13 are enriched with terms related to chromatin modification, chromatin organization, and chromatin assembly and disassembly.
After TSA 6 h treatment, categories were enriched which contained genes with functions in histone modification, chromatin organization, transcription regulation and cell cycle control.
However, how chromatin modifications and chromatin organization are reprogrammed upon fertilization in mammals has long remained elusive.
There is a growing awareness that histone modifications and chromatin organization influence pre-mRNA splicing.
Our data indicate that increased levels of histone acetylation around origins induce local modifications in chromatin organization, creating a more accessible structure.
A plethora of recent studies have revealed that mutation rates and genomic instabilities in cancer are directly related to aberrant histone modifications and chromatin organization, underscoring the importance of the histone code in maintaining genome stability (Lukas et al., 2011; Papamichos-Chronakis and Peterson, 2013).
However, other categories, including chromatin modification (GO 0016568) and chromatin organization (GO 0006325) were specific to piRNA producing genes.
Furthermore, we speculate that an epigenetic signature, comprised of TF occupancy, histone modifications, and overall chromatin organization, is an underlying mechanism that governs cardiac morphogenesis and disease.
Some possible relations between modifications of the chromatin organization during carcinogenesis and tumor progression and an increase of the FD of stained chromatin are suggested.
Though the mechanisms governing nuclear organization are not well understood, it is apparent that epigenetic modifications coordinately modulate chromatin organization as well as transcription.
Additionally, these structures have been linked with epigenetic modifications, such as chromatin organization through enrichment at condensed chromatin marked by histone H3 serine 10 (H3S10) phosphorylation in yeast, C. elegans and human HeLa cells [ 33], centromeric heterochromatin [ 34], and formation at promoter CpG islands lacking DNA methylation [ 16].
