Similarly, among genes identified as more responsive to aphids in the mutants than in wt, transcripts connected to transport, cell wall modification, cell division and development and cytoskeleton organisation were more induced in both mutants.
> -wrap-foot> The nonpersisting isolate 3001 contained 12 unique nonsynonymous SNPs in genes involved in transcription, translation, post-translational modification (cell division protein ftsh), energy production and conversion, protein turnover, amino acid transport, and metabolism (table 3).
On the other hand, more genes potentially regulated by breast cancer cell type specific enhancers (MSEL) were involved in mitosis, cell cycle, DNA replication, chromatin modification, and cell division process.
On the other hand, of the genes that we proposed to be under the control of MDAMB231 specific enhancers, a greater proportion were classified as being involved in mitosis, cell cycle, DNA replication, chromatin modification, and cell division, compared to HMEC selective genes (p ≤ 0.03).
When we compared MDAMB31 selected genes and randomly chosen overexpressed genes in MDAMB231 (n = 342), the gene ontology categories found above (i.e. mitosis, cell cycle, DNA replication, chromatin modification, and cell division) were not differentially enriched between MDAMB231 selected genes and random data set (Additional file 2: Table S15).
Epigenetic memory relies upon the faithful inheritance of epigenetic marks (such as DNA methylation or histone modifications) during cell division.
However, no DEGs were found for "RNA processing and modification", "cell cycle control", "cell division", "chromosome partitioning", "nuclear structure", "defense mechanisms", "extracellular structures and intracellular trafficking", "secretion", and "vesicular transport".
Thus to assess whether such changes in PABP1 pI occur under physiological conditions, we examined its modification status during cell division, when extensive translational regulation is manifest [ 28].
The function of the Polycomb repressive complex 2 (PRC2) is to tri-methylate lysine 27 on histone H3 (to create H3K27me3), which is a histone modification maintained during cell division [ 31].
When grouped into COG categories [ 37], the largest number of genes within the genome of the S. velum symbiont was associated with metabolism of coenzymes, transcription, posttranscriptional modification of proteins, cell division, DNA replication, and energy metabolism.
By maintaining such histone modifications through cell divisions, the cell state can then be epigenetically transferred from generation to generation, eventually establishing tissues and complex organisms.
