In the protein modification category, most genes were identified as kinases (68%) and phosphatases (9%).
Among the additional specific functional categories, only genes related to posttranslational modification (category O), like chaperones, seemed to retain a good vertical signal.
Bigelowiella natans proteins assigned to the posttranslational modification category consist of seven peptidyl-prolyl cis-trans isomerases (PPIases), six of eight subunits of the cytosolic chaperonin complex CCT, and several heat shock proteins.
There was significant effect modification between weight change category and weight in the preceding round for the weight gain group compared to the weight stable group, but not for the weight loss group.
We also investigated evidence of this potential effect modification using categories of lifetime exposure days across the entire follow-up period.
There were no effect modifications by categories of road traffic noise, gender, age, education, SES or prior diagnosis of cardiovascular disease.
The consistency in the trend of the associations between these epigenetic modifications and categories of available determinants, especially arsenic exposure and metabolism, suggests the need for understanding which of the two measures is a better biomarker for environmental epigenetic effects in future large-scale epidemiologic studies.
We used a similar strategy to examine effect modification by family history category, comparing women with a hereditary family history of cancer with women without such a family history.
We therefore proposed to combine the T-classifications of the TNM6th and N-classifications of the TNMc2008 with slight modifications (merging category T2a and T2b into T2, and category N3a and N3b into N3).
In stratified analyses, we found evidence for effect modification by family history category (Table 3).
