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This subcelllular localization is dependent of protein farnesylation which is a post translational modification catalysed by the farnesyl transferase enzyme.
Citrullination is a post-translational modification catalysed by peptidylarginine deiminase and is a common feature of inflammation.
One genomic feature that Rad9 detects is methylation on H3K79, a modification catalysed by Dot1 (Nguyen and Zhang, 2011).
The targeted epitopes are generated by a post-translational modification catalysed by the calcium-dependent enzyme peptidyl arginine deiminase (PAD), which converts positively charged arginine to polar but uncharged citrulline.
PARylation [poly(ADP-ribosyl)ation] is a post-synthetic modification catalysed by a family of enzymes known as PARP [poly(ADP-ribose) polymerases] [ 1] and made reversible by the activity of PARG [poly(ADP-ribose) glycohydrolase] [ 2].
This hypothesis is also sustained by the genome-wide colocalisation between macroH2A1 and the trimethylation of lysine 27 of histone H3, the histone posttranslational modification catalysed by PRC2 [ 13, 30].
Similar(53)
All types of posttranslational modifications catalysed by 2OG-dependent dioxygenases involve a common type of hydroxylation reaction.
The N termini of the core histones protrude from the nucleosome and are subjected to a range of covalent modifications, catalysed by various histone-modifying enzymes.
Wobble base modifications catalysed by yeast Trm9 and ALKBH8 proteins play important roles in stress signalling pathways, with responses to DNA damage and reactive oxygen species as prime examples (Begley et al, 2007; Chan et al, 2010; Fu et al, 2010a; Songe-Moller et al, 2010).
m6A modification is catalysed by METTL3 and enriched in the 3′ untranslated region of a large subset of mRNAs at sites close to the stop codon5.
This modification is catalysed by the Ezh1/2 components of the polycomb repressive complex 2 (PRC2).
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