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Pri-miR-142 can be modified by A to I editing by ADAR and this modification can inhibit Drosha processing [37].Thus, it is possible that site-specific modification by ADAR or other unidentified proteins may facilitate alternative processing.
The bases display a variety of nucleophiles that, upon modification, can inhibit enzymatic sequence replication or promote depurination.
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In addition to this, some modifications to histones can inhibit transcriptional factor binding.
The surface modification can also inhibit the non-specific adhesion between silica gel surface and BMVC molecule due to charge repulsion, thus increase signal-to-noise ratio.
Azithromycin, with minimal modification, can rapidly inhibit merozoite invasion at concentrations comparable to some of the best and most selective invasion inhibitors available for drug development and research.
To explore the importance of the posttranslational modifications of SP1 in the induction of HB-EGF expression and to search for compounds that can inhibit such modifications, a preclinical study should be performed using combination therapy with CRM197, irinotecan, and a compound that inhibits SP1, such as arsenic trioxide or bortezomib.
Also, chemical modification of titanium surfaces with zinc can inhibit bacterial colonization (Petrini et al. 2006).
Monoclonal antibody (mAb) IIH6 (available from the Developmental Studies Hybridoma Bank at the University of Iowa) is widely accepted to recognize specifically an LG domain-binding modification on α-dystroglycan because it can inhibit the binding of laminin (Ervasti and Campbell 1993).
In multiple cell lines, statins can inhibit prenylation (post-translational modification) of multiple proteins, including those in the Ras family, which is involved in signal transduction and presumed to be important in carcinogenesis [ 31].
In addition some proteins are palmitoylated in osteoblasts and the modification can be inhibited by the substrate analog inhibitor, 2BP.
In addition, the chemical damage and modifications that FFPE DNA may suffer from can inhibit the enzyme-dependent chemistries necessary for a number of approaches [ 11].
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