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It has also been shown that not only the amino acid composition of a protein but also its subsequent modification can influence the elution behaviour of proteins in ion exchange chromatography, e.g. by glycosylation which might lead to the shielding of surface charges [18].
This modification can influence a protein's steric structure and cause changes in protein-protein binding affinities and enzyme activities [ 1].
Epigenetic changes, including DNA methylation and histone modification, can influence gene expression independently from the genetic code.
Additionally, it has been postulated that therapeutic interventions and cardiovascular risk modification can influence myocardial blood flow or flow reserve of the heart [ 20– 20].
Evidence from the Framingham Heart Study, the WHO MONICA Project and elsewhere has also shown that behavioural modification can influence metabolic risk factors for CVD [ 10- 12].
Many general initiation factors are involved in translation initiation, and their concentration or posttranslational modification can influence translational efficiencies of many genes [ 43, 44].
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These so-called epigenetic modifications can influence a variety of traits, such as obesity and sexual preference.
Overall, this study shows how structural modifications can influence hydrolysis of short peptides, thus pointing to the need for further research on controls on peptide hydrolysis in the environment.
It has been known that changes in H3K9Ac and H3K9Me2 modifications can influence the chromatin structure and affect gene expression [31], and these epigenetic modifications in specific loci could be critical for determining the fate of stem cells [20].
Epigenetic modifications can influence gene expression and alter cellular function without modifying the genomic sequence.
Epigenetic modifications can influence gene expression without changing the genome sequence.
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