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Ubiquitination is a posttranslational modification by which specific lysine residues of the target protein are conjugated to polyubiquitin chains, using specific cellular ubiquitin conjugation systems.
The first BEA describes the modification by which a CC bond becomes a CH bond with CO release; the second defines the inverse reaction.
Finally, we confirmed that harmine and harmaline possess posttranslational modification by which they reduce the CYP1A1 protein stability in human hepatoma HepG2 cells [ 9, 10].
DNA methylation is an epigenetic modification by which a methyl group is added to a cytosine base at the carbon-5 position in a CpG dinucleotide.
Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) was performed using a vertical gel apparatus according to the method of Laemmli [ 23], with modification by which gelatin was included in the resolving gel.
In construction of an HtBv ligand the covalent modification by which two targeting moieties are linked should have a minimal effect on the binding of each moiety to its respective target.
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The jaws of many atheriniforms are protrusile, but the structural modifications by which this is achieved are quite different from those of typical acanthopterygians.
To investigate the biological function of miR-26b in HCC cells, we used Huh7/Hep3B cell line with medium-level of miR-26b expression for both knockdown and overexpression modifications, by which subsequent functional analyses could be performed comparatively among miR-26b-overexpressing, -silenced, and NC control cells that had the same parental genetic background.
The measurements extracted from each groan were used to determine the suitable modification factors by which to modify the groans.
Many proteins are targeted for covalent modification by SUMO, which consequently modulates many cellular processes [2] [4].
An interaction term was added to the model to assess effect modification by sex, which was not confirmed.
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