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We examined effect modification by statin use, obesity, and diabetes.
Effect modification by statin therapy also was examined.
Effect modification by statin use was not assessed because of incomplete data.
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Models used to examine effect modification by obesity, diabetes, and statin use included interaction terms that allowed associations between BC and the outcomes to vary among subgroups.
The potential risk modification by concomitant treatment with metformin, statin and angiotensin converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB) was also evaluated.
No effect modification on statins by ischaemic heart disease or congestive heart failure was shown.
Also the activity of matrix-metalloproteinases in atherosclerotic lesions of New Zealand rabbits was detectable by SPECT and allowed monitoring of dietary modification and statin treatment [29].
We used interaction terms to evaluate effect modification by prerandomization medication use, namely, diuretics, statins, glucose-lowering medications, and medications that block the RAAS (e.g., ACE inhibitors and angiotensin receptor blockers [ARBs]).
No differential effects were observed by statin class or treatment duration [ 13, 29] but interaction analyses revealed potential effect modification by HRT with a larger absolute dense volume among statin users who also reported HRT use.
Mitochondrial function may be impaired by statin therapy, and this effect may be exacerbated by exercise.
Surprisingly, both showed no significant reduction of the primary endpoint by statin therapy.
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