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The network for 'protein modification by small protein removal' in your query organism is displayed on the left, if relationships are supported by the integrated data.
Protein modification by small ubiquitin-like modifier (SUMO) plays a critical role in the pathogenesis of heart diseases.
These PTMs include phosphorylation, methylation, acetylation, PARylation, ubiquitination and modification by small ubiquitin-like modifiers (SUMOs).
The 'protein modification by small protein conjugation or removal' group, which contains all mRNAs of the 'protein polyubiquitination' and 'protein ubiquitination' groups, shows the most significant p-value.
In comparison to females, males in the rested state demonstrated higher expression levels of genes which enriched GO terms relevant to protein modification by small protein removal.
In contrast to the previously listed GO terms that are linked with certain topological characteristics, 'Acetylation' and 'Protein Modification by Small Protein Removal' terms are significantly linked with multiple topological characteristics.
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In addition to the global regulators PhoP-PhoQ and PmrA-PmrB, recently regulation of the Kdo2-lipid A modification enzymes by small RNAs (sRNAs) and small peptides in certain bacteria has also been reported.
This finding suggests that covalent modification(s) by small chemical group(s), which we believe cause the slight molecular weight shift of the 32-kDa procaspase-3-D3A, could have a major role in the Photofrin-PDT-mediated suppression of caspase-3 activity.
Modification by SUMO (small ubiquitin-like modifier) has also been linked to topoII regulation, with work in S. cerevisiae indicating that the topoII major modification sites (K1220, K1246/K1247 and K1277/K1278) again lie in the C-terminal domain [14].
Recently, the enzymes that constitute the thymidylate synthesis cycle were shown to undergo post-translational modification by the small ubiquitin-like modifier (SUMO) and nuclear translocation during S and G2/M phases [7], [8].
Ubiquitination could also be influenced by impacting upon related pathways, such as protein modification by the small ubiquitin-like modifier-1 (SUMO-1).
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