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Kar2 contains a conserved cysteine thiol that is susceptible to redox modification by several candidate modifiers including hydrogen peroxide and glutathione, but it still remains elusive which modification of Kar2 provides protection against oxidative stress.
We exploited a unique and essential feature of Wnt proteins, their covalent modification by several lipids, to package the purified proteins in a manner that both stabilizes and enhances their in vivo biological activity.
Effect modification by several prespecified variables was investigated by formal tests of interaction.
There was an indication of effect modification by several study conditions.
We used multiplicative interaction terms and likelihood ratio tests to evaluate evidence for effect modification by several factors.
Then, city-specific estimates were included in a random effect meta-regression analysis to investigate the effect modification by several city characteristics.
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HDL particles are subjected to modifications by several lipase and lipid transfer proteins, particularly, LPL, HL, CETP and PLTP (phospholipid transfer protein).
It is recognized that histone modification is catalyzed by several enzymes which modulate the histone markers.
Histone modifications are mediated by several protein complexes, which target specific sequences through interactions with gene promoters and transcription factors [ 119, 120].
NAD+-dependent post-translational protein modifications are catalyzed by several enzyme families, including PARPs and the sirtuin family of NAD+-dependent class III histone deacetylases (SIRTs) [ 8, 65, 66].
In this study of the effects of PM2.5 interactions with asthma and COPD candidate genes and hypertension medication use on ΔSBP and ΔDBP, we observed significant effect modification by PM for several genes and for ARB use.
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