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We found no evidence of effect modification by obesity status (for nonobese, adjusted HR = 0.68; 95% CI: 0.32, 1.44; for obese, adjusted HR = 0.85; 95% CI: 0.41, 1.78; pinteraction = 0.68).
There was no evidence for effect modification by obesity on the association between 25(OH D and the inflammatory or hemostatic outcomes (p>0.13 for all comparisons).
Improved air quality and attenuated lung function decline: modification by obesity in the SAPALDIA cohort.
For diabetes and metabolic syndrome, we additionally considered effect modification by obesity (< 30 vs. ≥ 30 kg/m) status.
However, no effect modification by obesity status was observed when we stratified the participants to diabetic and non-diabetic.
Additionally, we observed evidence of effect modification by obesity on the association between traffic pollution exposure and decreased parasympathetic tone.
Similar(42)
In stratified analyses of the effects of lifetime home SHS exposure (Table 4), there was little evidence of effect modification, except by obesity, with stronger relationships among obese participants.
Next, we evaluated the presence of effect modification by race, obesity, and impaired fasting glucose at baseline status using multiplicative interaction terms in a Cox proportional hazards model.
Our finding on the effect modification by maternal obesity is consistent with literature that lean or normal weight women with higher blood pressures have smaller offspring compared to their obese counterparts [ 6].
The effect modification by maternal obesity on fetal growth restriction, may be due to the higher fetal nutrient supply in obese women [ 30], and the overall effect of maternal obesity and blood pressures on birth weight may be dependent on the balance of these factors [ 6, 29].
However, Egan et al (1999) reported that only larger breast sizes in lean women prior to the first full-term pregnancy were associated with increased risk of breast cancer, and commented that studies that lacked an associated between breast size and breast cancer did not consider the effect modification by overall obesity.
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