At that the surface modification is controlled by numerous parameters like loading force, friction coefficient, tool's tip radius, strain rate, and number of tool passes.
On the contrary, if these genes are present in distantly related genomes (e.g. genomes from different bacterial phyla), this may point to either an ancient origin of this modification in Bacteria followed by numerous independent secondary losses, or to a recent origin followed by horizontal gene transfer across bacterial phyla.
Promoter activity may also be regulated by numerous modifications of the histones associated with the promoter.
N-myristoylation is a crucial covalent modification of numerous eukaryotic and viral proteins that is catalyzed by N-myristoyltransferase (NMT).
Extensive research has been done to improve the biocompatibility and blood circulation of iron oxide nanoparticles by numerous surface modification and functionalization strategies for various biomedical applications [13, 14, 15, 16, 17, 18].
Also, Collagen molecules undergo postranslational modification along the secretory pathway by numerous Collagen-modifying enzymes such as glycosidases, and lysyl- and prolyl-hydroxylases, required for trimer formation (Myllyharju and Kivirikko, 2004).
As a continuation of our efforts directed to the structure-activity relationship studies of vitamin D compounds, we present in this paper the synthesis of new analogues of 1α,25- OH 2D3 characterized by numerous structural modifications, especially a cleaved D ring.
HSF1 activity is modulated not only by interactions with chaperones but also by numerous posttranslational modifications including phosphorylation, acetylation, and sumoylation [ 56].
The introduction of non-natural entities into proteins by chemical modification has numerous applications in fundamental biological science and for the development and manipulation of peptide and protein therapeutics.
Darwin was mindful of Paley's relation argument when in the Origin of Species he stated: "If it could be demonstrated that any complex organ existed, which could not possibly have been formed by numerous, successive, slight modifications, my theory would absolutely break down.
Darwin famously noted in 1859 (p.189) that "if it could be demonstrated that any complex organ existed, which could not possibly have been formed by numerous, successive, slight modifications, my theory would absolutely break down".
