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Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients.
We tested for and found no effect modification by gender and therefore show results for women and men combined.
Through such comparisons, we found an effect modification by gender on the association between increased hemoglobin and elevated ALT.
Moreover, the slope of the correlation lines between accumulated number of individuals with elevated ALT and hemoglobin level for two genders is steeper for male adolescents than that for females (22.95 vs. 6.27 in Figure 2), indicating an effect modification by gender.
No effect modification by gender was observed.
Similar analyses found no effect modification by gender.
Similar(21)
a gender by Cd interaction on urinary levels of DPD and Ca indicated no effect-modification by gender (p for interaction ≥0.3).
We tested the gender by Cd interaction on urinary levels of DPD and Ca but no effect-modification by gender was observed (p ≥ 0.3).
We first examined possible effect modifications by gender and other variables.
Since potential effect modifications by gender were expected, gender was contained in the model, although its main effect was not significant.
Modifications by gender has also been studied, and some investigators reported no difference by gender [ 14], while others found men in Santiago and Sao Paulo [ 15] specifically for circulatory causes [ 35] or women in various locations [ 15- 17, 19, 24, 36] to be at higher risk for mortality.
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