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Cox proportional hazard models were used to estimate risk of each cancer with individual nutrients and to explore possible effect modification by combinations of nutrients on cancer risk.
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Specifically, the study looked into how much of the variation in gene expression can be explained by combinations of three different histone modifications.
The authors also highlight the value of using an expert pathologist who can rule out 'incidental pathology' (i.e. related to the background strain or environment and not the genetic modification) by a combination of comparison to control animals and prior experience.
A process was investigated for producing high modulus, high strength, dimensionally stable poly ethylene terephthalate) (PET) filament by combination of threadline modification and post drawing techniques.
Figure 16 Compression result with sidelobe suppression by combination of phase predistortion and spectrum modification.
Preparation of 68Ga for labelling of 10, 11 and 12 was performed by combination of previously described methods [34],[35] with minor modifications.
Formally, this hypothesis states that one modification or specific combinations of histone modifications can affect distinct downstream events by altering the structure of the chromatin and/or generating a binding platform for protein effectors that can specifically recognise the modification(s) and initiate gene transcription or repression.
Ultimately, individual tRNA species must be isolated and analyzed for changes in tRNA-modification levels in an analysis of the regulatory properties of modified ribonucleosides, and this is accomplished by quantitative localization of modifications using combinations of RNase cleavage and oligonucleotide-based affinity purification along with LC MS analysis.
Therefore, it was necessary to find a term for any chemical modification and any combination of chemical modifications.
Stunning numbers of reversible modifications along with different combinations of modification involving physical interactions of enzymes and regulatory proteins in both directions throws insights of complexity of epigenetic regulation by histone modification (Patra and Szyf 2008; Kouzarides 2007).
In addition, the expression kinetics can be fine-tuned by different combinations of chemical modifications [24].
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