Sentence examples for modification by alternative from inspiring English sources

Pretranslational modification by alternative splicing, alternative promoter usage and RNA editing enables the production of multiple protein isoforms from a single gene.

Transcriptional modification by alternative splicing is known to be involved in the regulation of apoptotic cell death in mammalian cells as well (Jian g and Wu, 1999).

Exons 5 9 code for a small mRNA of 1.1 kb, which is susceptible to modification by alternative splicing and downregulation by promoter methylation.

Such disorder-based signaling is further modulated in multicellular eukaryotes by posttranslational modification and by alternative splicing, both of which very likely occur much more often in IDRs compared to structured regions of proteins [ 25, 32].

In sensitivity analyses, we evaluated effect modification by age using alternative age at explosion cut points ranging from 5 to 13 years.

The many other mechanisms that the cell uses to introduce variation at gene or transcript or protein level (such as RNA editing and post-translational modifications) are themselves affected by alternative splicing (for example, introduction of protein domains that bring about post-translational modifications [ 5]).

However, basal resistance to TMV in N. benthamiana was not affected by modification of alternative respiratory capacity.

Thus deficiencies in technical performance that arise from unanticipated demands and/or unintended consequences may be addressed not only by modification of the infrastructure but also by alternative strategies that obviate the need for such modification.

A change in the operating pathway occurs in response to a DNA damage signal followed by checkpoint activation and is realized by alternative covalent modifications of PCNA (Hoege et al. 2002; Watts 2006; Andersen, Xu and Xiao 2008; Zhang et al. 2011) and the different affinity of DNA polymerases for its modified forms (Garg et al. 2005; Parker et al. 2007; Acharya et al. 2011).

SPF45 is also phosphorylated by CLK1 on multiple serine residues and this posttranslational modification regulates alternative ss utilization by SPF45 and its intranuclear localization [ 115].

NMD is often triggered by alternative splicing (AS) modifications introducing such codons.