From the very beginning, Kochi says, she wanted it to be open source, so that anyone could use it, modify it, and then share those modifications more broadly.
As demonstrated in Fig. 2B, Zfp277 as well as the PcG proteins and their histone modifications were broadly distributed across the Ink4a/Arf locus in presenescent MEFs.
ChIP-on-chip analyses revealed that both histone modifications were broadly enriched over the c-myb promoter and first intron in HPC7 cells but restricted to the intronic HS-D domain in FMH9 cells.
Histone modifications are broadly divided into positive and negative marks that are typically correlated with the levels of productive and nonproductive gene expression, respectively (Ernst et al., 2011; Zhou et al., 2011).
On the other hand, biosafety regulators do not consider epigenetic regulation (e.g. DNA methylation, ncRNAs and histone modifications), which are broadly known to affect gene expression, within their risk assessment analyses.
With his modifications in place — broadly, the generality interpretation of free variables, the removal of individual constants, and the relocation of Generalization and Necessitation into the logical axioms themselves — Kripke is able to demonstrate that his system is sound and complete relative to his semantics.
These modifications techniques may be broadly classified into three major classes; namely, physical immobilization of biological material, chemical modification, and modification of materials using energy possessing substances like plasma, ion implantation, and so forth were highlighted in the coming subsections.
This simple and effective surface modification strategy will be broadly applicable in cellular engineering and biosensing studies employing hydrogel micropatterns.
Upon entry into meiosis, active modifications started to accumulate broadly on the Akap4 locus with the induction of modest transcription.
Historically, it was proposed that these histone modifications could provide a code, termed appropriately the histone code, which could dictate biological outcomes through protein-protein interactions with modification-specific binding proteins, broadly called readers.
