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A series of novel hedgehog signaling pathway inhibitors have been designed by structural modification based on the former reported scaffold of 4- 2-pyrimidinylamino benzamide.
Consequently, we calculate the linear parameters in question classically by means of the Moore-Penrose inverse matrix with the modification based on the calculus of the dual numbers formulated in [22].
This study identifies the presence and absence of landscape principles of Defensible Space theory in the chosen effected premises and provides modification based on the said theory in the existing guideline for the kindergarten landscape development in Malaysia.
This article provides an overview of the methods for surface modification based on the use of stable radicals: 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and its derivatives.
To further elaborate the structure activity relationship of selective JMJD3 inhibitors and to explore the novel chelating groups for Fe(II) ion, we initialized a medicinal chemistry modification based on the GSK-J1 structure.
Morphological studies conducted using Atomic Force Microscopy (AFM) consistent with the proposed modification based on the structural changes found on the GCE surface, as well as to the obtained differences of roughness parameters (Rq values).
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Additionally, all the modifications based on the original GA aim to achieve a better balance between efficiency and reliability.
To solve these problems, a set of novel modifications based on the A* family algorithms was proposed.
Next, by following the methods in [16] and [17] with some modifications, based on the concept depicted in Eqs.
First, chemical modifications based on the adjustment of the pH and the design of prodrugs are presented and discussed.
The algorithm, which has been implemented by a fuzzy logic controller, computes the handover margin modifications based on the faulty cell and the neighboring cell performance.
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