Sentence examples for modification at this from inspiring English sources

In the HOXC cluster the other study found increased DNA methylation changes, which suggested none or low H3K27me3 modification at this locus, again supporting our findings of very low H3K27me3 in the whole cluster and high H3K4me3 in the N terminal part of this cluster in PC3 cells.

However, the brain pericytes did not exhibit any noticeable modification at this level.

Additionally, the high-resolution X-ray crystal structure of dihydroquinazolinone bound to the CREBBP bromodomain indicated that modification at this position would direct substituents into the ZA channel.

Furthermore, the ERK2 kinase binds stably to Tpr's tail and was proposed to have a role in cargo modification at this location (Vomastek et al, 2008).

Significantly, other small RNA studies have found extensive evidence for mismatch at position 9, which suggests that posttranscriptional modification at this position is common [ 30].

Terminal alkyne modifications were employed in place of the C20 27 aliphatic chain of cholesterol since modification at this position can be tolerated in ShhC autoprocessing.

From these results, we designed and synthesized other 3″-modified analogues of cADPcR having a substituent at the 8-position and found that this modification at the 8-position made them partial agonists.

The latter was however not restricted to subtelomeres, as we observed a comparable decrease of this modification at the heterochromatic CT47 macrosatellite repeat array (Fig. S2A ).

Together, these data suggest that, in this locus, maintenance of H3K4me3 requires processive replication and that the retention of this modification at the promoter is required for wild-type levels of expression.

However, because we did not observe any increase of this modification at the MyoG and mCK regulatory regions during muscle differentiation, we ruled out the possibility that H3S10ph functions in muscle gene activation (Additional file 2E).

If so, the parasite must have evolved mechanisms to stall RNAPII despite the presence of the Ser2/5-P modification at the CTD since this form of the polymerase, just as for the unphosphorylated and Ser5-P forms, is enriched at a subset of genes at times when their mRNA levels are low.