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They play an important role in gene regulation by covalent modification at several sites and histone variants replacement.
In yeast, Trm4p is not site-specific and introduces this modification at several positions in tRNA molecules [ 106].
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Preparation of single cell cDNAs was performed based on previously published protocols with modifications at several steps (Tang et al., 2009; Tang et al., 2010).
Thus, sRNAs control the LPS biosynthesis and its modifications at several levels.
Detailed ChIP analysis of the chromatin modification status at several endogenous centromeres revealed that alphoid DNA appears more euchromatic in HT1080 cells than in HeLa.
However, this modification was observed at several sites in the pericentromere in the transformed cell lines, HT1080 and a lymphoblast (EBV-transformed) line LT690 [24](Fig. 2).
The A380 test aircraft have participated in a campaign of airport compatibility testing to verify the modifications already made at several large airports, visiting a number of airports around the world.
Second, we address the engineer estimate and look at several modifications of our sample.
Different PilE modifications have been reported at several serine residues in meningococcal strains, including glycosylation at position 63 and an α-glycerophosphate at position 93.
Altering expression of several TFs to have a higher level of induction upon the stress stimuli, or higher cell-specific constitutive expression, could be feasible by introducing enhancer elements by genome editing using the CRISPR/Cas9 system that allows the simultaneous modification of several genes at the same time.
Conceptual advance comes from our finding that PON2 modulates execution of the cell death program directly at the mitochondria, thereby allowing modification of several apoptotic pathways converging at these organelles.
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