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The m1A modification at position 947 of the 16 S rRNA was proposed to be important for human mitochondrial ribosome subunit stability and is catalyzed by TRMT61B30.
By synthesizing a MD with an atactic pendant hexyl group at position 3, the influence of a modification at position 6 compared to a modification at position 3 towards ROP was investigated.
Additionally, amyloid-β peptides with a pyroglutamate modification at position 3 and oxidation of Met35 make up a substantial portion of sporadic AD amyloid deposits.
The most potent inhibitors of mycobacteria growth was compound 5 with one electron-neutral 1,2-dicarba-closo-dodecaborane modification at position 1 of thymine, and compound 8 with two modifications, at position 1 and 3.
β- S-Methyl thioaspartic acid occurs as a posttranslational modification at position 88 in Escherichia coli ribosomal protein S12, a position that is a mutational hotspot resulting in both antibiotic-resistant and antibiotic-sensitive phenotypes.
The second one has been designed in order to evaluate the influence of modification at position 12 where different short linkers have been introduced on the Huprine X, Y skeletons.
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In plants, histone H3 modification at positions Lys-9 and Lys-14 is positively correlated with gene activation, and the deacetylated status with inactive transcription [ 33].
The histidine modification at positions 13 and 14 of Aβ40, therefore, increases its avidity to fibrillar Aβ40.
Some of these modifications are cell cycle specific, with modification at S1354, S1357, S1364 and T1366 being increased during mitosis, and modification at positions T1259, S1273, S1270 and S1267 increasing in G1 [7].
However, chemically different modifications at position 34 would expand the ability of a tRNA to read three or even four of the fourfold degenerate codons.
A series of oleanolic acid analogs, characterized by structural modifications at position C-3 and C-28 of oleanane skeleton were synthesized and assessed for antiinflammatory potential towards lipopolysaccharide (LPS) induced nitric oxide (NO) production in macrophages.
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