Whether this was because of increased gene expression, increased translation or post-translational modification is unclear.
Altogether the control of Hh range of action by cholesterol modification is unclear: in the Drosophila embryo it is admitted that cholesterol modification increases Hh range of action.
The significance of this modification is unclear, but is believed to reduce the affinity of histone H1 for chromatin [ 11, 12].
Objective: Modification of eating behavior in Japan is promoted to prevent overweight and obesity, but the effects of such modifications are unclear.
The relationship of these two types of modifications is unclear.
The functional significance of these modifications is unclear and varies from system to system.
Whether this is a distinct NOS isoform coded by mitochondrial DNA or whether it represents nNOS translocated to mitochondria with specific post-translational modifications is unclear [ 7].
The functional role of these modifications is unclear, but it has been postulated that these modifications may affect the interaction with IGFs, the acid-labile subunit, and cell surface or matrix components [ 23].
The use of glucosamine in the management of OA remains controversial and its specific mechanism of action in OA pain and function modification are still unclear.
