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Both TF binding and histone modification are predictive of gene expression levels [26].
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As histone modifications are predictive of gene functions, we decided to examine the epigenetic signatures at var and rifin genes.
Karlic, R. R. Chung, H., Lasserre, J., Vlahovicek, K. & Vingron, M. Histone modification levels are predictive for gene expression.
Thus, a crucial research challenge is to identify the epigenetic modifications that are predictive of long-term adverse effects.
Distribution patterns of histone modifications in gene body are predictive of gene functions.
Moreover, evidence obtained by immunohistochemistry suggests that differences in global histone modification patterns in cancer tissues are predictive of clinical outcomes and associated with the risk of tumor recurrence (reviewed in [ 109]).
Our results indicate that both histone modification features and transcription factor binding features are predictive for chromatin accessibility with high accuracy and these chromatin features are highly redundant.
The previous analyses suggest that both histone modification features and transcription factor binding features are predictive for chromatin accessibility with high accuracy in DNase I hypersensitive sites.
"Both are predictive in nature".
Cardiac microtissues are predictive of structural cardiotoxicity.
First, specific histone modifications must be predictive of transcription, even if not directly causative, rather than just reflecting transcriptional states determined by other epigenetic factors.
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