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Physiological and molecular analysis in combination with genetic modification are planned to shed further light on the roles of the various signalling pathways.
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Timing and dose modification were planned on the basis of toxicity registered.
No dose modification was planned for localised or peripheral oedema, but the patient could be withdrawn at the discretion of the investigator.
Indeed, EA has already changed several feature-sets in response to the closed beta, and other modifications are planned.
Future modifications are planned to enhance this tool.
Dose modifications were planned for haematological and non-haematological toxicity.
No dose modifications were planned for local treatment.
No dose modifications were planned for trastuzumab during the course of the study, unless a patient experienced a toxicity not specified in the protocol.
Said modifications were planned to be controlled solely by changes in the chain structures, i.e. they would result from the specific types of the raw materials employed: diisocyanates, polyols and chain extenders.
In case of G1 toxicity or first occurrence of G2 toxicity lasting <7 days, no dose modification or delay was planned.
Enantiospecific syntheses of these compounds were reported previously and could be adapted for the synthesis of any hit compound, should it be developed further.[ 6, 7] To probe the SAR of starting compound 1, a number of modifications to the core were planned.
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CEO of Professional Science Editing for Scientists @ prosciediting.com