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Herein, seven analogues targeting anti-apoptotic Bcl-2 proteins derived from the Bim BH3 domain via sequence simplification and/or modification are described.
This measure and our modification are described in detail elsewhere [ 36].
Safety data, including data on treatment interruption and dose modification, are described in detail elsewhere (Cassidy et al, 2002).
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The modification is described by permittivity, ε: U a b = x a [ 1 ε ] g a b x b.
The effect of each modification was described in the same theoretical framework as the original model by introducing 'effective' quantities such as the effective mutation distance or the effective screening size.
This modification is described in the section that evaluates efflux of EB after addition of glucose or of agents that are being evaluated for activity against efflux of EB.
Glycosylation as a posttranslational modification is described as heterogeneous, structurally complex, widespread, and cell- and protein-specific process.
Histone modification is described as a balance between permanent modification and de-modification reactions of the histones of cooperatively acting nucleosomes (Binder et al., 2013).
Two cellulose synthase genes were over-expressed in bm3 or AS225 internodes whereas no drastic modification was described in cellulose content in bm3 plants.
The modification is described as follows: a 20 μl plasma aliquot was precipitated with 4 volumes of 5% trichloroacetic acid for deproteinization.
When 5mC is found at a cis-regulatory element, it has usually been found to be associated with the silencing of the associated gene [ 40], leading to the cytosine modification being described as repressive.
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