Ongoing management of this progressive disease, through medical supervision and diligent lifestyle modification, is critical so that patients can continue to lead active lives.
Small-diameter synthetic vascular grafts have high failure rate due to primarily surface thrombogenicity, and effective surface chemical modification is critical to maintain the patency of the grafts.
Since newly cleaved mica is negatively charged at basic pH [4], an advisable surface modification is critical to bind the negatively charged phosphate backbone of DNA.
Therefore, selecting a proper site for marker modification is critical for successfully constructing the marked viral infectious clone.
Further, MOMP from various chlamydial species is glycosylated (mainly D-mannose-rich) and this modification is critical for MOMP adhesion [ 34- 36].
Because CSPG4 could be covalently attached to chondroitin sulphate glycosaminoglycan (GAG), we wanted to know whether this modification is critical for TcdB toxicity.
Post-translational modification is critical for the functioning of membrane proteins, yet for PMP22 this aspect has not been investigated in detail.
We found that this modification is critical for Saw1-mediated UV resistance partly due to collaboration with another DNA nuclease, Slx1-Slx4.
The uH2B-K123 modisicriticals critical for H3K4 methylation by SET1, possibly acting to open the chromatin structure for SET1 targeting [ 18].
Posttranslational modification is critical for regulating the localization, stability, and activity of proteins, as well as their ability to form macromolecular complexes (Walsh 2006).
Our findings indicate that ERK phosphorylates ERG through an interaction with the DEF domain and this modification is critical for ERG to promote prostate cell migration.
