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Other mechanisms of protein modification are NO-dependent.
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Nitration of tyrosine or nitrosylation of cysteine residues are NO-dependent post-translational modifications that can positively or negatively regulate protein function [ 5, 6], and this can occur by diverse mechanisms.
There were no dependents.
There are no time-dependent signals.
There are no modifications... It's very simple.
This modification was dependent upon PAD4 because PAD4 KO mice exhibited no staining for citrullinated histone H4.
However, this modification is a context-dependent process.
The U.S. is no longer dependent on Saudi oil.
Intriguingly, some of these histone modifications are dependent on p53.
Context-dependent epigenetic modification is fundamentally different from germline-dependent epigenetic modification.
Although NO's ability to modify biological molecules has proven to be physiologically important, NO-dependent modifications may contribute to cell death through S-nitrosylation of proteins or the formation of peroxynitrite.
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