Sentence examples for modification and thereby from inspiring English sources

The objective of the work is to obtain models that would help to design new thazolidine derivatives based on substituent modification and thereby predict their activity profile.

These proteins are likely mediators of CpG signalling that influence chromatin modification and thereby genome activity.

Methylated DNA sequence will allow the preferential binding of methylated DNA binding proteins (e.g., MeCP2 and MBD2) and histone deacetylases leading to the nucleosome remodeling and histone modification and thereby hindering the accessibility of the transcription machinery [ 23].

The TET enzymes thus appear to have functions beyond DNA demethylation, involving the recruitment of proteins acting on histone modifications and thereby on gene expression.

Chromobodies can, in principle, detect any antigenic structure, including posttranslational modifications, and thereby dramatically expand the quality and quantity of information that can be gathered in high-content analysis.

However, protein redox events are elusive and difficult to capture due to their labile and oxygen sensitive nature [ 63, 64]; cell lysis can disrupt the native redox context of the cell, significantly perturbing or destroying sensitive modifications and thereby producing non-biologically relevant artifacts.

While the authors were unable to conclude whether this high redox buffering capacity of protein thiols is the work of a few high abundance, highly cysteine-enriched proteins or a contribution of the majority of thiol-containing proteins, our data suggest that the majority of yeast protein thiols have the capacity to undergo reversible redox modifications and thereby serve as redox buffer.

A second group of proteins that contain modular domains are capable of recognizing or "reading" this phospho-modification information and thereby linking the kinase signal to downstream molecules.

Sulf-1 and Sulf-2 are novel extracellular sulfatases that act on internal glucosamine-6-sulfate (6S) modifications within HSPGs and thereby modulate HSPG interactions with various signaling molecules, including Wnt ligands.

It is thus tempting to speculate that the initially reversible thiol modifications that we observe in chronologically aging yeast cells might in fact represent a 'pro-active' response of yeast cells to protect their proteins against irreversible protein modifications and damage, and thereby extend lifespan.

We have also studied the consequences of treating human cells with drugs that change the histone modification profile of heterochromatin and thereby affect HP1 localization.