Sentence examples for modification and stabilization from inspiring English sources

Hsp90 is a molecular chaperone that plays an important role in the modification and stabilization of a variety of proteins implicated in tumor cell proliferation and survival.

The expression level of BRCA2 is presumably regulated through various mechanisms including transcription, subcellular localization, binding to partners, and protein modification and stabilization.

Interestingly, the most frequent common gene mutations detected so far in ccRCC were either functionally related to histone modification and stabilization, thus mechanisms indented with expression states of genes and DNA methylation 22, or, as in case of VHL, were demonstrated to cause an increase in epigenetic alterations including DNA methylation 23.

Increased TG activity can result in increased modifications and stabilization of aggregated and monomeric mutant huntingtin as well as oligomers of mutant huntingtin fragments.

6 Examples include enhancement of metabolic stability, functional-group (FG) reactivity or acid/base-property modification, and conformational stabilization.

In various normal adult tissues, basal levels of p53 protein are low, but specific stress signals induce post-translation modifications and its stabilization, leading to activation of distinct transcriptional programmers.

Due to their unique properties, hydrophobins are also of interest for biotechnological applications, e.g. modification of surface properties and stabilization of foams and emulsions (Linder et al. 2005).

On treatment with staurosporine, only wild-type cells are able to induce genes involved in several ER-related functions, such as "protein folding and stabilization," "modification with sugar residues (e.g., glycosylation, deglycosylation)," "ER to Golgi transport," and "cellular export and secretion", suggesting an ER-mediated stress response that is not induced in Δ czt-1.

This is could be due to the extra time needed for translation and export of the protein but may reflect some additional regulation of those processes including transcript stabilization, posttranslational modification, secretion, and stability of the protein in the culture fluid.

These genes are related to the cellular sensing and response to external stimuli, stress response and protein folding, stabilization, modification and degradation; certainly in response to the stress promoted by N deprivation (described below).

Differential modulation of noncatalytic roles, post-translational modification, and catalytic activity through stabilization of discrete ATP-binding sites with particular inhibitor classes allows for greater control of aberrant signaling enzymes.