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For example, the high intramitochondrial pH may be one reason mitochondrial protein thiols are particularly susceptible to modification and play a key role in cell signalling [ 146, 147].
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Ubiquitination is an important post-translational protein modification and plays a crucial role in various processes such as cell cycle, signal transduction, and transcriptional regulation.
Asparagine (Asn/N -linked glycosylAsn/N -linkedmportant posttranslational modification and plays a crucial role in protein foldinglycosylationty, cell–cell recognision, signanimportantother cellular posttranslationalryote (Nguyen et al. 2011; Rayon et al. 1998; Schwarz and Aebi 2011; Breitling and Aebi 2013).
Protein phosphorylation is a widespread posttranslational modification and plays a key role in regulation of cellular functions.
Histone methylation is a very important post-translational modification and plays an essential role in chromatin remodeling, gene transcription and genome stability in eukaryotic cells [ 1– 3].
It functions as a transcriptional repressor through chromatin modification and plays a role in axial patterning, cell cycle regulation, hematopoiesis, and senescence [ 11, 12].
Protein phosphorylation catalyzed by protein kinase is one of the most important post-translational modifications and plays a significant regulatory role in many vital biological processes.
Shape modification and deformation play an important role in the filed of geometry modeling, computer graphics, conceptual design and so on.
Glycosylation appears as an important mechanism of protein modification and may play a role in protein maturation and protein function in Leishmania [ 45].
In P. luminescens, this TCS controls the expression of the pbgPE operon which is involved in lipid A modification and thus plays a role in colonization and infection of the invertebrate hosts [ 18, 31].
The histone modification markers (HDACs) are evolutionarily conserved enzymes that remove acetyl modifications from histones and play a central role in epigenetic gene silencing (Hayakawa and Nakayama 2011).
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