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Prevention and control rely upon the disruption of transmission through vector management, environmental modification and modification of human behavior to minimize exposure.
These modifications techniques may be broadly classified into three major classes; namely, physical immobilization of biological material, chemical modification, and modification of materials using energy possessing substances like plasma, ion implantation, and so forth were highlighted in the coming subsections.
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The number of modified nucleosomes nHM out of the NH cooperative nucleosomes associated with the regulatory region of gene i is calculated by solving: (2) Here, kD and kM are the de-modification and modification rate, respectively.
However, due to the comparably low cellular abundance of mitochondrial tRNAs the study of their modifications and modification pathways lags far behind that of cytoplasmic or bacterial tRNAs.
Due to RNA bias editing, 5' modifications and 3' modifications, many pre-miRNAs produce multiple mature miRNA isoforms, namely isomiRNAs, as described in many studies [ 48– 50].
Other complex regulatory mechanisms such as post-translational modification, chromatin modification, and microRNA regulation may also explain what we observed.
Conformational modification, morphology modifications, and reduction of the Coulombic interaction by a screening effect were proposed to explain the conductivity improvements [13, 15 18].
We also report highly significant relationships between module membership and epigenetic modifications (histone modifications and promoter CpG methylation status), which are known to play a role in controlling gene expression during ES cell self-renewal and differentiation.
Figure 3 reports significant relationships between module membership, chromatin structure and epigenetic modifications (histone modifications and DNA methylation), which are known to play a role in controlling gene expression during ES cell self-renewal and differentiation.
This randomized blinded clinical study was designed to compare the efficacy of tolterodine treatment combined with behavioral modification, behavioral modification alone and behavioral modification plus placebo in children with nonneurogenic, nonanatomical voiding dysfunction.
It should be also noted that we focused only on direct effect modification, and thus, the present discussion does not necessarily apply to other types of effect modification, i.e., indirect effect modification, effect modification by proxy, and effect modification by a common cause [ 22].
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