Cardiac rehabilitation (CR), a multidisciplinary program consisting of exercise, risk factor modification and psychosocial intervention, forms an integral part of managing patients after myocardial infarction (MI), revascularization surgery and percutaneous coronary interventions, as well as patients with heart failure (HF).
Consequently, it was assumed that, by extension, raising HDL-C through lifestyle modification and pharmacologic intervention would reduce risk of CVD.
Whether life-style modification and drug intervention alter these oxidant status markers awaits further investigation.
Compared to FRS, cardiovascular risk stratification based on the metabolic scoring is composed of more modifiable cardiometabolic risk factors and prone to lifestyle modification and health intervention.
1, 2 Accordingly, the goals of lifestyle modification, and therapeutic intervention when required, are to improve those risk factors known to be important in improving macrovascular outcomes.
In the present article, the murine models for Sjögren's syndrome (SS) are presented along the lines of spontaneous and extrinsic-factor induced models of SS-like disease and are discussed with special focus on disease phenotype and alterations induced in association with genetic modification and experimental intervention.
This empirical work speaks to the growing diseasification of risk that molecular screening technologies facilitate, with risk 'treated' in much the same way as disease itself, through medical means such as medication, behaviour modification and surgical intervention (Armstrong, 1995; Sachs, 1995; Clarke et al, 2003, 2010; Aronowitz, 2009; Sulik, 2011; Gillespie, 2012).
As a result, healthcare providers can intervene with dose modification and other interventions, increasing the likelihood that patients will remain on treatment for a longer period of time without significantly disrupting their overall quality of life.
The incidence of falls increases with greater numbers of intrinsic and extrinsic risk factors and can be reduced by risk modification and targeted interventions.
