Sentence examples for modification and inhibition from inspiring English sources

This modification and inhibition is not just limited to MFN2, as Parkin-mediated ubiquitination of MFN1 has also been reported (Gegg et al., 2010; Glauser et al., 2011).

It remains unproven whether modification and inhibition of MEKK1 plays a singular role in the effects of ITCs in apoptosis or cancer chemoprevention.

The mechanism responsible for this repair downregulation can be at least partially explained by the reported c-Abl-mediated modification and inhibition of several members of the DSB repair machinery.

The wiring diagram also includes the Jak/STAT independent induction of STAT1 expression by IFN-γ. Figure 8B also gives a simplified wiring diagram to show the processes of slow STAT1 synthesis, STAT1 activation through covalent modification, and inhibition from SOCS1 whose synthesis is activated by STAT1.

The latter effects have been observed in other cell types and ascribed to oxidative modification and inhibition of E1/E2 enzymes (11) and SUMO-specific proteases (SENPs) (12), respectively, but the hypersumoylation response on exposure of HESCs to relatively low levels of ROS has not yet been described.

A small increase in inhibition was observed with this modification, and the inhibition results have been rationalised by induced-fit docking.

Light activation of DNA-bound dye molecules results in irreversible DNA modification and subsequent inhibition of its amplification.

Recently, thiol modification and consequent inhibition of two protein phosphatises, PTP1B and MAPK phosphatase MKP-1, dependent on Nox4-generated ROS, have been demonstrated in endothelial cells and fibroblasts respectively [50,51].

Using primary cultures, we show that modest levels of reactive oxygen species (ROS) increase sumoylation in human endometrial stromal cells (HESCs), leading to enhanced modification and transcriptional inhibition of the progesterone receptor (PR).

Aspects of plant phenotype, such as root architecture modifications and growth inhibition in transgenic plants, influenced by imbalance between CKs accumulation and distribution can partly explain tolerance to various environmental stresses.

The disturbances in the membrane assembly lead to changes in fluidity and permeability, modifications of ion transport, and inhibition of metabolic processes, altogether revealed to be the collective consequence of reactive oxygen species formed during lipid peroxidation [ 42].