Sentence examples for modification and inactivation from inspiring English sources

Chemical modification and inactivation of aminoglycosides by many different enzymes expressed in pathogenic bacteria are the main mechanisms of bacterial resistance to these antibiotics.

Also in ricin the A-chain represents the enzymatically active component, leading to modification and inactivation of 28S ribosomal RNA [31].

The nucleophilic attack of 5-LOX by LTA4 leads to the covalent modification and inactivation of the enzyme [ 98].

Photofrin-PDT can trigger the immediate production of ROS, which are directly involved in the modification and inactivation of procaspase-3.

The proteasome is known to be susceptible to oxidative modification and inactivation, so we presume that the severity of this DMC-induced oxidative stress may contribute to its more potent impairment of proteasomal activity.

CES1 is reported to have neutral cholesteryl ester hydrolase activity in macrophages and is highly sensitive to covalent modification and inactivation by OP poisons that react with the active-site serine residue.

hemicholinium mustard is a substrate for CHT that causes covalent modification and irreversible inactivation of the transporter.

Subsequent studies have demonstrated that diabetes, hyperglycaemia and arterial hypertension result in lower endothelial eNOS (endothelial NO synthase) protein activation, but increased O-GlcNAc modification (and possibly inactivation) of eNOS [ 67– 67].

Whereas low yields in homologous systems may be caused by the need for submerged cultures, heterologous systems face challenges such as codon usage bias, the need for signal peptides, protein accumulation as inclusion bodies, the absence of necessary post-translational modifications, and enzyme inactivation during purification (Brijwani et al. 2010; Piscitelli et al. 2010).

These results suggest that the GDF15-mediated enhancement of the IK amplitudes was not associated with the modification of the IK activation and inactivation properties.

Peroxycarbonate is subsequently reduced to an enzyme-bound carbonate radical, CO3–, which leads to fast modifications of active-site residues and inactivation of the enzyme.