Sentence examples for modification and cellular from inspiring English sources

By contrast, the linkage between protein modification and cellular response is poorly understood.

In contrast, almost all differentially expressed genes being involved in the carbohydrate metabolism, protein modification and cellular component organization were significantly down-regulated.

The antioxidant stress response is activated by oxidative stress (Section  3.1.1) and culminates in the neutralization, modification, and cellular export of oxidized/oxidizing compounds and/or potentially hazardous products of oxidation reactions (Section  3.1.2).

To prioritize our studies of the relation between protein modification and cellular responses, we constructed expression vectors containing individual response elements upstream of the luciferase gene, which we transfected into RKO cells prior to treatment with HNE.

Although how TNF-R signals on the cell surface activate the IKK complex is not completely understood, studies have identified most key signaling components, and uncovered post-translational modification and cellular translocation of these components [ 14].

This assumption is however not always true, since the activation or inhibition of a target gene by a TF can be influenced by not only the mRNA expression of the TF and their targets, but also by post-transcriptional modification of the genes, as well as the concentration, post-translational modification and cellular localization of their protein products.

In contrast, the disease targets are usually larger, multidomain proteins, often in larger assemblies, and with heterogeneities of chemical modifications and cellular environments.

Thus there is a continued need for the development of sensitive and user-friendly methods for cataloguing biomacromolecules in complex environments and for detecting their interactions, modifications, and cellular location.

Epigenome editing is a promising approach for durable gene regulation, with many applications in basic research including the investigation of the regulatory functions and logic of chromatin modifications and cellular reprogramming.

Similar approaches are likely to enable these analyses for other dynamic modifications and cellular lineages.

More studies will be required to discover the cross-talk connections between modifications of histones and DNA and between these modifications and cellular functions.