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The longevity of state memory could thus be tuned by evolving the number of modifiable sites in the target protein of the circuit (in addition to changing rate constants).
Determining modifiable risk factors and optimal management for those who are more likely to suffer from early demise will be central to changing the overall mortality.
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We focused on health system (clinic-level) and contextual barriers to changing provider behavior in relation to key processes associated with TB diagnosis, and used the PRECEDE framework to classify modifiable barriers as predisposing, enabling and reinforcing factors that could be targeted with clinic-level interventions [ 22].
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It has also become clear that several epigenetic marks are modifiable, by changing the exposure in utero, but also by lifestyle changes in adult life, which implies that there is the potential for interventions to be introduced in postnatal life to modify unfavourable epigenomic profiles.
The fact that some gene expression are modifiable without changing the actual genetic code, it's the expression that is modified by outside impacting effects like how we live, eat, sleep, etc.
For instance, if the reference data are biologically largely meaningless (as in the case of a very poor classification) or if the gene used is unresolved at the taxonomic level of interest, the agreement between reference and clustering partitions might be hardly be modifiable by changing the clustering parameters.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com