In addition, although lacking in statistical significance due to low sample size, both smoothed mx and total % of females laying eggs were modestly larger for the resistant group when replicates are combined.
Platinum plus gemcitabine, previously described as modestly active in platinum-resistant ovarian cancer [ 23– 25], was administered to 38 of 73 patients (52%) who received further platinum-based combinations.
The sensitive group had modestly higher expression of EGFR compared to the resistant xenografts (1.5-fold higher, P < 0.001), but there was no difference in pEGFR expression (P = 0.905).
TB treatment programs are grappling with how to scale up new tools: rapid, more sensitive diagnostic tests; shorter, effective prevention strategies; and a modestly expanded portfolio of treatment options for drug-resistant TB.
In both HCT116 and LoVo cells, changes in [H]-D-Asp uptake upon SN38 resistance development were quantitatively more pronounced than the changes in SLC1A1 protein level, and in oxaliplatin-resistant HCT116 cells, SLC1A1 expression was modestly increased, yet [H]-D-Asp uptake modestly decreased.
Moreover, RA patients with even modestly elevated CRP levels (>1.92 mg/L) are more insulin-resistant than those with lower CRP levels [40].
Importantly, mice lacking MYC-335 were resistant to intestinal tumors, although MYC transcripts were only modestly reduced.
Once castration-resistant prostate cancer (CRPC) develops, secondary androgen manipulation, immunotherapy, and chemotherapy have been modestly effective.
In contrast, trastuzumab-resistant cells, which retain high levels of phosphorylated EGFR/HER1, HER2, and HER3, are only modestly growth-inhibited by AIIB2.
