Sentence examples for modestly reduced level from inspiring English sources

In contrast to existing ankyrin-null or hypomorphic mouse mutants, hema6 is unique in that only wild-type ankyrin protein was produced in mutant erythrocytes at a modestly reduced level.

However, we have shown that in Traf3-deficient MEFs, RNA viruses can still activate IRF3 normally and induce IFNβ at a modestly reduced level (Zeng et al., 2009).

Moreover, he noted that the drug only very modestly reduced levels of a nasty protein called tau in the spinal fluid.

Several other mutants display modestly reduced levels of dityrosine in their spore walls, consistent with the idea that these mutants have defects in organization of the outer spore wall layers.

In the presence of proteasome inhibitors, cells with modestly reduced levels of PSMD2 had a strong competitive advantage.

Complete loss of telomerase is tolerated for several generations in most species, but modestly reduced telomerase levels in human beings are implicated in bone marrow failure, pulmonary fibrosis and a spectrum of other diseases including cancer.

A previous study has demonstrated that NEDD4 proteins can ubiquitylate and reduce AMOT p130 levels (Wang et al., 2012), and we also observed that OSF-NEDD4L overexpression modestly reduced AMOT p130 levels.

In both Lox and SKO mice, this RD diet intervention dramatically reduced hepatic retinol and retinyl ester stores to less than 0.25% of the hepatic stores observed in mice fed the standard diet (Figure 2D), but in comparison only modestly reduced plasma retinol levels in both Lox and SKO mice (Figure 2C).

In contrast, knock-out mice in which the iE/MAR or the 3'E were deleted individually showed normal or only modestly (2- to 2.5-fold) reduced levels of SHM, respectively [20].

However, the ubiquitination levels were modestly reduced in K6R hESCs, supporting the notion that the C-terminal lysine residues are targeted for ubiquitination (Fig. 5D).

Reduction of RPS51 mRNA levels only modestly reduced cell growth, suggesting that yeast RPS51 may be synthesized in excess under normal conditions, and this synthesis can compensate partially for the reduction in mRNA levels [29].