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The CRC cell line LOVO showed modestly increased levels of SGK1 expression (3.7 to 6.2-fold), while the RIE-1 cell line, which was used as a control as it is derived from normal small intestinal cells of rat origin, showed a prominent increase in Sgk1 levels (average fold change = 21; t-test p-value = 1.2×10−5) as expected from previous reports (Fig. 1a).
We observed modestly increased levels of ROS in MLH1-deficient cells exposed to cytarabine after 2 h of treatment.
Treatment for 24 h at lower levels of MI192, close to its IC50 (500 nM), modestly increased levels of acetylated tubulin.
Two additional markers, RBP1 and LRG1, were detected at modestly increased levels (approximately 1.2- to 1.5-fold) in affected twins compared to either unaffected twins or unrelated controls.
A second approach was launched in the 1970s, based on experiences from these early prevention trials and a recognition that most CVD cases occur in the large part of the population with only modestly increased levels of several risk factors.
It should be noted that MDA-MB-231 cells, which are TNBC with intact RB function, express markedly high levels of Smurf2 mRNA and modestly increased levels of the protein with rapid turn-over.
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Extending the treatment to 72 hrs resulted in modestly increased level of reactivation (lanes 6 and 7).
Inflamed, compared with noninflamed, colonic biopsies showed strongly increased transcript levels of CSF3 and modestly increased transcript levels of IKZF3, whereas the transcript levels of ERBB2, GRB7, MIEN1, and PGAP3 were modestly decreased.
Chronic co-infection with hepatitis B was associated with modestly but significantly increased levels of alanine aminotransferase, but did not otherwise impact the clinical picture.
Treatment with paclitaxel led to increased Puma and modestly increased Bim levels at 8-12 h and decreased Bcl-2 levels at 48 h of treatment in T47D cells.
Mice treated with vancomycin without VRE colonization displayed modestly increased plasma levels of TNF-α and IL-10.
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