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In contrast to that of K8R, the interaction between p53 and Mdm2 is only modestly increased in K6R hESCs, indicating that acetylation within the core domain plays a key role in disrupting the interaction between p53 and Mdm2 (Fig. 5C).
Despite the finding that p53-Mdm2 isteraction is modestly increased in K6R cells, p53 is more stable in K6R cells with reduced ubiquitination when compared to wild type p53, indicating that the C-terminal lysine residues are the preferential targets for ubiquitination.
ZO-1, another tight junction protein, was also modestly increased in spheroids.
The expression of Bid, Bak and Bax was not changed in spheroids whereas the expression of Bcl-xL was modestly increased in spheroids.
In young mice, increased Bax expression results in dramatic thymic lymphopenia concordant with previous findings [19] which was modestly increased in p27 −/− mice.
It was recently demonstrated that miR-29b was dramatically down-regulated in the region of the fibrotic scar after MI and collagen expression in the heart was modestly increased in response to miR-29b inhibition [31].
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This is driven entirely by declining heights in Africa; with half of countries in South America showing stagnation in height since 1945 and heights modestly increasing in the rest of the world.
Co-delivery of GM-CSF DNA appeared to slightly decrease the overall frequency of dual-functional CD8+ T cells in the blood of vaccinated macaques but modestly increase in the frequency of triple cytokine expressing HA-specific CD4+ (16% in the GM-CSF adjuvanted group vs. 11% in the unadjuvanted group) and CD8+ T cells (8% in GM-CSF adjuvanted group vs. 5% in unadjuvanted group).
The two principal polymeric mucins in the airway are Muc5ac, which is produced at low levels under healthy conditions but increases greatly in allergic inflammation or parasitic infection, and Muc5b, which is produced at substantial levels under healthy conditions and modestly increases in allergic inflammation [ 8, 9].
Likewise, dilp6 conditionally expressed in head fat body modestly increased lifespan in females upon high-yeast diet (Fig. 2D,F) and less so upon low-yeast diet (Fig. 2C).
We found that NLK is able to robustly increase mutant AR aggregation in DHT-treated neurons, while it only modestly increased aggregation in the absence of hormone.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com