Exact(1)
We report that while mutation to Ala or Gly abolishes activity, mutation to Phe and Tyr only modestly impacts kcat and Km.
Similar(59)
"Most of the businesses are only modestly impacted by the crisis," says Pzena, who spent a decade in equities research at Sanford C. Bernstein and took over the Classic Value Fund in 1996.
Next, EPA's efforts to minimize duplicative animal testing in the Endocrine Disruptor Screening Program were minimal and will only modestly impact the number of animals used.
Our findings also suggest that RLM patterns are only modestly impacted by small modifications in physical constraint.
Interestingly, while antibody levels were substantially reduced in the absence of IL-6, plasma cell development was modestly impacted (6% vs. 5%; B6 vs. B6 + αIL-6; P = 0.2056).
While the choice of parcellation obviously impacts our detailed results, use of alternative parcellations would only modestly impact our main conclusions.
Overall, the current interventions and organizations very modestly impact the health status of chronic patients and the access to and use of adequate services.
In an effort to dramatically cut the latter while modestly impacting the former, the U.S. Environmental Protection Agency EPAA) is proposing regulations that would set the first national standards for emissions of toxic substances from about 525 power plants.
On the contrary, studies have shown that EPA regulations generally have a modestly positive impact on the economy and jobs.
But we are persuaded by the report's core finding that the benefits of selling gas to other countries would more than offset the modestly negative impact of higher prices for domestic users of the fuel.
Indeed, KRAS and PIK3CA mutations were not associated with worse OS, possibly because 82% of patients received another regimen after progression on cetuximab-based treatment or because response to cetuximab impacts modestly on the natural history of mCRC.
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