In our colony, disease progression in these mice was modestly delayed (by a few weeks) as compared to what was reported by Wang et al, [4](Table 3), the PBCre4×Ptenflox/flox mice developed invasive carcinomas and adenocarcinomas at a time when the ARR2PBCreER(T2)×Ptenfl/fl mice treated with OHT at 2 wks of age, were starting to develop microinvasive carcinomas.
In prior studies of mice that harbor the APPswe and mutant PS1 transgene constructs utilized here, we have noted that transfer of the transgene from the hybrid background to C57BL/6J mice modestly delays the onset of amyloid deposition to lower amyloid loads at younger ages [34].
Depletion of IL13Ralpha2 in metastatic breast cancer cells modestly delayed primary tumor growth but dramatically suppressed lung metastasis in vivo.
In mouse models of lupus, BAFF inhibition only modestly delays the onset of an anti-double-stranded DNA autoantibody response and these antibodies are still capable of deposition in the kidneys [ 16, 17].
As reported previously, acyclovir suppression did not reduce HIV-1 transmission to uninfected partners in spite of a 0.25 log10 reduction in plasma HIV-1 levels [ 17], but modestly delayed progression in HIV-1 infected persons [ 18].
Although postprandial suppression of EGP is modestly delayed and is not appropriate for the prevailing glucose concentration, the absolute rate of postprandial EGP was only minimally greater in diabetic than in nondiabetic subjects.
By contrast, in terminally differentiated shATM ihNSCs, the number of γ-H2AX foci 30 min following DNA damage is greater than in control cells, while the resolution of the foci is only modestly delayed (Fig. 2B), suggesting a minor dependence on ATM for DSB repair.
SCC FAK −/− cells in which a FAK kinase-deficient mutant was re-expressed (SCC FAK-KD) initially grew and then regressed with kinetics that were only modestly delayed when compared to FAK −/− cells, indicating that immune suppression depends on FAK kinase activity.
However, group delay was modestly reliable only for adults.
Bevacizumab, accompanied by chemotherapy, is able to prolong life marginally in colon cancer and to delay progression modestly in several other cancers.
