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Specifically, re-introduction of mir-200c into A549 cells does not change morphology, modestly changes expression of members of the EMT network (E- and N-cadherin, ZEB1, or Snail), and slightly improves response to EGFR inhibition.
Generally, the total protein content is only slightly depressed relative to wild type kernels [ 12, 17, 18], and knocking down 19- and 22-kDa α-zeins in high or low protein lines by RNAi only modestly changes total protein content from the parental levels, suggesting that total protein content is under genetic control [ 17].
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Treasury believes that tax cuts modestly change how much firms shift profits overseas; it may overstate how much tax cuts flow into additional profits rather than higher wages in those industries that it does recognise as oligopolies; and it may discount the benefits of investors making less distorted choices between debt and equity funding.
Once the protein's physical and chemical environment is modestly changed, the rigid structure of a protein will unfold into random coils [8, 10].
Exposure to LB1 or to TMZ only modestly changed these distributions, with TMZ causing a slight increase in G0/G1 and S phase cells and a slight reduction in G2/M phase cells.
Excluding the missing responses from the relevant analyses only modestly changed the point estimates.
The initial dynamics of Cdk1-driven centrosome separation were only modestly changed in the presence of the Plk1 inhibitor.
Expression of CCL5 was only modestly changed by the MCD diet in WT mice on both genetic backgrounds.
The majority of genes were modestly changed (fold change: -2.9 to 3.2), an effect particular to neurobiological tissue [ 27] and consistent with previous studies [ 24, 28- 30].
In contrast to the destabilising effect of STCA on HER2 and RAF1, the levels of the kinases GSK3 α and GSK3 β were only modestly changed.
Figure 1C and G shows clusters of genes that are induced by 5FU in both cell lines and either unchanged or only modestly changed in DOX-treated lines.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com