These results provide empirical support for the assertion that modest weight losses of 5 10% of initial weight are sufficient to produce significant, clinically relevant improvements in CVD risk factors in overweight and obese patients with type 2 diabetes.
Even though a modest weight loss of 5-10% of the baseline weight is reported to have significant positive effects on comorbid conditions [ 6], many patients undergoing lifestyle interventions do not reach this goal [ 7].
If a pre-diabetic state is detected, a modest weight reduction (of the order of 10%), combined with a more physically active lifestyle, may prevent or retard the development of overt diabetes.
The E 300 BlueTEC Hybrid's drivetrain brings a modest weight penalty of 60 kg, all of it at the front, because Mercedes has managed to squeeze all of the hybrid-specific parts, including the battery, under the bonnet, so that they don't interfere with passenger or luggage space.
Nevertheless, the decrease in body weight explains part of our results as a modest weight reduction of 5-10% was demonstrated to be enough to improve insulin resistance [ 34].
The Diabetes Prevention Program (DPP) showed a greater than 50% reduction in the incidence of diabetes with a weight management/exercise program for high risk adults, demonstrating that a relatively modest weight loss of 3-4 kg (equivalent to 5% of initial body weight) could prevent diabetes [ 56].
Modest weight loss of 5%to10%0% will reduce the risk of diabetes by up to 60% and can reduce low-density lipoprotein cholesterol by 15% and triglycerides by 20%to30%0%, increase high-density lipoprotein cholesterol by 8%to10%0%, and reduce blood pressure by around 5%.
A difference of 20% was chosen because this is the degree of difference in SSPG concentration seen with modest weight loss of 7% (17).
124, 125 Approximately 150 minutes of aerobic exercise per week resulted in a modest weight loss of approximately 2 3 kg, whereas PA >225 420 min/wk resulted in 5 7 kg weight loss.
For an obese individual, the ADA recommends a modest weight loss of 5%10%% body weight, while physical activity can help attenuate loss of lean body mass that can occur with energy restriction.
