Hypercaloric high fat feeding in dogs resulted in modest weight gain, and an increase in adipose tissue with no change in the non-adipose tissue size.
The study also demonstrated that even modest weight gain during adulthood, independent of physical activity level, was associated with increased mortality.
Additionally, a modest weight gain during the first 18 months after diabetes diagnosis was associated with an increased risk of incident AF.
Modest weight gain during adulthood has been associated with a higher risk of coronary heart disease, stroke, breast cancer[ 4- 6] and possibly an increase in mortality[ 7].
Increasing evidence that type 2 diabetes may be prevented or delayed by lifestyle modification interventions designed to achieve modest weight loss and increase physical activity serves as the premise for large-scale interventions (116– 116).
The Diabetes Prevention Program (DPP) was a randomized clinical trial that successfully demonstrated that modest weight loss and increased physical activity could reduce the incidence of diabetes in a group of pre-diabetic patients by 58% [ 6].
Weekly albiglutide significantly improved glycemic control with an acceptable safety and tolerability profile and modest weight loss without increasing the risk of hypoglycemia or immunological response in subjects with type 2 diabetes.
Evidence from landmark clinical trials such as the Diabetes Prevention Program has shown that type 2 diabetes can be prevented in high-risk patients by lifestyle changes that result in modest weight loss and increased physical activity (1, 2).
Body weight increase was modest (2.1 kg insulin degludec; 2.0 kg insulin glargine; not statistically significant).
